Search results for "Microbispora sp. ATCC-PTA-5024"

Metabolic pathways and regulatory networks associated to NAI-107 lantibiotic production in Microbispora sp. ATCC-PTA-5024

2015

The filamentous actinobacterium Microbispora sp. ATCC-PTA-5024 produces the lantibiotic NAI-107, which is effective against multidrugresistant Gram-positive pathogens. In actinomycetes, the biosynthesis of antibiotics is elicited as a physiological response that is controlled by a complex regulatory network involving general and pathwayspecific regulators. The ‘omics technologies can be useful to explore molecular physiology in bacterial cells and elucidate molecular and metabolic events associated to antibiotic production in order to develop robust and economically-feasible production processes. To this aim, differential proteomic analyses, based two-dimensional difference in gel electroph…

Proteomics to elucidate the molecular physiology of Microbispora sp. ATCC-PTA-5024, the producer of NAI-107, a very promising lantibiotic

2015

The filamentous actinobacterium Microbispora sp. ATCC-PTA-5024 produces the lantibiotic NAI-107 (Maffioli et al., 2014), which is effective against multidrug-resistant Gram-positive pathogens (Jabés et al., 2011). In actinomycetes, the biosynthesis of antibiotics is generally elicited as a physiological response controlled by a complex regulatory network involving global regulators, playing pleiotropic roles, and pathway-specific regulators, which activate the biosynthesis of biologically active molecules (Bibb, 2005)

Microbispora sp. ATCC-PTA-5024 proteomic analysis to study metabolic pathway changes before and during lantibiotic production

2011